sinusoidal obstruction syndrome treatment
Ragoonanan D, Khazal SJ, Abdel-Azim H, McCall D, Cuglievan B, Tambaro FP, Ahmad AH, Rowan CM, Gutierrez C, Schadler K, Li S, Di Nardo M, Chi L, Gulbis AM, Shoberu B, Mireles ME, McArthur J, Kapoor N, Miller J, Fitzgerald JC, Tewari P, Petropoulos D, Gill JB, Duncan CN, Lehmann LE, Hingorani S, Angelo JR, Swinford RD, Steiner ME, Hernandez Tejada FN, Martin PL, Auletta J, Choi SW, Bajwa R, Dailey Garnes N, Kebriaei P, Rezvani K, Wierda WG, Neelapu SS, Shpall EJ, Corbacioglu S, Mahadeo KM. 2013;119(15):2728-2736. J Med Case Rep. 2008;2:227. P30 CA016672/CA/NCI NIH HHS/United States. Bone Marrow Transplant. Anticancer Res. Katzka DA, Saul SH, Jorkasky D, Sigal H, Reynolds JC, Soloway RD. Seguchi M, Hirabayashi N, Fujii Y, et al. VOD/SOS was reported in 11% of patients who underwent HSCT, with no cases diagnosed outside the HSCT setting.41 In postmarketing data, the incidence of VOD/SOS and fatal hepatotoxicity increased in various settings (GO before HSCT, GO after HSCT, and GO without HSCT.) Br J Haematol. Transplantation. Feasibility of allografting in patients with advanced acute lymphoblastic leukemia after salvage therapy with inotuzumab ozogamicin. A randomized, double-blind, placebo-controlled trial. 1996;18(4):755-760. Br J Haematol. Although SOS does not usually present with focal lesions on radiological images, the present study describes the case of a 22-year-old woman with oxaliplatin-induced SOS mimicking metastatic colon cancer in the liver. Please enable it to take advantage of the complete set of features! Prospective studies in children and adults showed mixed results,62 but a systematic review and meta-analysis of 12 studies in which unfractionated heparin and low-molecular-weight heparin were used for prophylaxis of VOD/SOS showed that anticoagulation did not significantly reduce the risk for VOD/SOS (RR, 0.90; 95% CI, 0.62-1.29).63, Antithrombin (AT) has a protective effect on the vascular endothelium, and levels are low in VOD/SOS. Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network and the Pediatric Diseases Working Party of the European Society for Blood and Marrow Transplantation. Defitelio ® (defibrotide sodium) is indicated for the treatment of adult and pediatric patients with hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), with renal or pulmonary dysfunction following hematopoietic stem-cell transplantation (HSCT).. 23. 79. Here we discuss the implications of these therapies with regard to the incidence of VOD/SOS. Thorax. Found insideThis is another attempt of InTechOpen to continue the dissemination of international knowledge and experience in the field of immunology. Patients with a median age of 25 years (range, 0.2-70 years) received a median daily dose of defibrotide of 25 mg/kg (range, 10-80 mg/kg) for a median of 15 days (range, 1-119 days). Resten A, Maitre S, Humbert M, et al. Am J Med. Sun Q, Luo M, Gao Z, Han X, Wu W, Zhao H. BMC Pulm Med. Found insideBased on the results of studies on autoimmunity, the endocrine system, nutrients, metal metabolism and intestinal bacterial flora, this volume thoroughly covers studies on functional correlation of the liver with the spleen, visceral fat, ... The diagnosis is suspected in patients with unexplained clinical or laboratory evidence of liver disease, particularly in those with known risk factors, such as bone marrow or hematopoietic cell transplantation. 1 INTRODUCTION. PLoS One. Approval summary: gemtuzumab ozogamicin in relapsed acute myeloid leukemia. 57. PVOD occurs in a wide variety of patients and has been reported in association with pre-existing exposure to chemotherapy, especially to bleomycin, cisplatin, carmustine, cyclophosphamide, and mitomycin.26 It also has been reported following autologous HSCT and allogeneic HSCT (allo-HSCT).27-30 The main feature that PVOD shares with VOD/SOS is vascular and endothelial damage. 72. These may lead to clinical manifestations such as exercise intolerance, hypoxemia, pulmonary hypertension, and right-sided heart failure.28,31 Although the pathogenesis is similar in the 2 conditions, PVOD is distinct from hepatic VOD/SOS. 83. Targeted therapy. Eur J Clin Pharmacol. Childrens Cancer Group, the Pediatric Oncology Group, and the Pediatric Intergroup Statistical Center. Hepatic sinusoidal obstruction syndrome (HSOS), also known as veno-occlusive disease or VOD, is a kind of hepatic vascular disease which is caused primarily by progenitors of toxic agents to bone marrow and liver sinusoidal endothelial cells (LSECs) (1,2). VOD/SOS may have a classic presentation, or the onset may be later. Defitelio is contraindicated in the following . Fatal veno-occlusive disease of the liver following high dose chemotherapy, irradiation and bone marrow transplantation. A placebo controlled trial, however, has not been done as of 2016. Bone Marrow Transplant. Found inside – Page iThis book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. 1998;128(12 pt 1):975-981. Rates of VOD/SOS were significantly higher in the patients who received GO (64% vs 8%; P<.001) than in those without GO exposure prior to HSCT.42 A retrospective review of 23 patients who were treated with GO for relapsed AML after HSCT noted that VOD/SOS was diagnosed in 35% of the patients. Found insideThe new edition of the highly successful Anaesthesia Science Viva Book incorporates this new clinical emphasis, giving candidates an insight into the way the viva works, offering general guidance on exam technique, and providing readily ... This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. Damaged sinusoids can be associated with a partial or complete occlusion of small hepatic veins, hence the previous denomination of hepatic veno-occlusive disease (VOD). Updated November 27, 2015. Treatment generally includes supportive care including pain management and possibly diuretics. Ursodeoxycholic acid, also known as ursodiol, is a hydrophilic bile acid that has been used for the prophylaxis and treatment of a variety of hepatic conditions, including VOD/SOS. However, no completely satisfactory strategies for the treatment of SOS have been established yet. 89. Medicine (Baltimore). We endorse universal adoption of paediatric diagnostic guidelines for sinusoidal obstruction syndrome as proposed by the EBMT, and provide implementation guidance for standardisation across centres; we have further proposed adjunctive use of age-appropriate organ-specific toxicity criteria for severity grading and provided prophylaxis and treatment considerations among children and adolescent and young adult patients. Purpose: Defibrotide is an agent used to treat sinusoidal obstruction syndrome (SOS/VOD) in patients undergoing haemopoietic stem cell transplantation. The response rate was 63%, with 58% alive at 100 days after HSCT.80 In another study, Myers and colleagues treated 9 children with methylprednisolone at 500 mg/m2 twice daily for 6 doses and reported responses in 6 of the 9 children.81 Therefore, high-dose methylprednisolone is listed as a therapeutic agent, with a recommendation category of 2C in the BSBMT guidelines.62. 1984;39(12):956-957. Learn more about our commitment to Global Medical Knowledge. 2012;51(2):195-198. Hepatic veno-occlusive disease, also called sinusoidal obstruction syndrome (VOD/SOS), is a potentially life-threatening and unpredictable complication of toxic injury mainly from conditioning regimens for hematopoietic stem cell transplantation (HSCT) [1,2].Although less common, VOD/SOS also may develop as a result of primary chemotherapy, immunotoxin conjugated therapies or radiation . Shahab N, Haider S, Doll DC. Pasquini M, Wang Z, Horowitz MM, Gale RP. Sinusoidal obstructive syndrome, also known as hepatic veno-occlusive disease, is a potentially life-threatening complication that occurs in children undergoing haemopoietic stem-cell transplantation (HSCT). 69. Differences in the incidence of genetic predisposition and clinical presentation of sinusoidal obstructive syndrome between children and adults have rendered the historical Baltimore and Seattle diagnostic criteria insufficient for children. Ruutu T, Eriksson B, Remes K, et al; Nordic Bone Marrow Transplantation Group. Prior gemtuzumab ozogamicin exposure significantly increases the risk of veno-occlusive disease in patients who undergo myeloablative allogeneic stem cell transplantation. Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life threatening complication that can develop after hematopoietic cell transplantation. Montani D, Achouh L, Dorfmüller P, et al. He subsequently developed sinusoidal obstruction syndrome (SOS) that resolved on discontinuation of XELOX treatment. Final report of the efficacy and safety of gemtuzumab ozogamicin (Mylotarg) in patients with CD33-positive acute myeloid leukemia in first recurrence. The EBMT criteria for late-onset SOS/VOD (Table 1) were developed following reports that 15% to 20% of cases were occurring more than 21 days after HSCT. Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients. The legacy of this great resource continues as the MSD Manual outside of North America. VOD/SOS developed in 12% of the treatment group vs 20% in control group (P=.05).73 Notably, the incidence of acute GVHD also was significantly lower in the treatment group (P=.0046), perhaps owing to the anti-inflammatory effects of defibrotide on the endothelial cells of the skin, gastrointestinal tract, and liver.73 A multicenter, prospective study that includes children and adults is ongoing, and results are eagerly awaited. Disease-specific mAb therapy has brought significant advances to cancer treatment, but it also has affected the incidence of VOD/SOS. Grupp S, Richardson PG, Kernan NA, Brochstein JA, Mineishi S, Termuhlen AM, et al. Blood 27(13):1656-1665, 2016. Hepatic sinusoidal obstruction after gemtuzumab ozogamicin (Mylotarg) therapy. Pulmonary hypertension: CT of IMPORTANT SAFETY INFORMATION. We report below on the literature. Blood. Sinusoidal obstruction syndrome due to graft-versus host disease may be treated by increasing the dose of drugs used to suppress the immune system or defibrotide sodium. 84. Graft-vs-host disease resulting from bone marrow or hematopoietic cell transplantation, Pyrrolizidine alkaloids in crotalaria and senecio plants (eg, medicinal bush teas) and other herbs (eg, comfrey), Other hepatotoxins (eg, dimethylnitrosamine, aflatoxin, azathioprine, some anticancer drugs). Despite all potential supportive therapies, PVOD remains incurable without a lung transplant.35, Risk Factors in the Era of Contemporary Therapies. tPA is not recommended owing to the high risk for bleeding, but high-dose corticosteroids, especially if initiated early, have shown compelling results. In 25%, sinusoidal obstruction syndrome is severe, accompanied by fulminant liver failure. Br J Haematol. 42. There is no specific treatment that has been shown to reverse sinusoidal injury and hepatocyte necrosis in patients with gemtuzumab ozogamicin-related SOS. Resten and colleagues reviewed high-resolution CT scans of the chest obtained from 15 patients who had pathologically confirmed PVOD and compared them with scans from patients who had primary pulmonary hypertension. Ask patients who have cryptogenic liver abnormalities about use of herbal and natural products (including bush and herb teas) and anabolic steroids (which can cause peliosis hepatis). Ann Surg. 10. The initial lesion is a result of endothelial denudation, corresponding to the migration of . Long-term treatment with 6-thioguanine (6-TG) for pediatric acute lymphoblastic leukemia (ALL) is associated with high rates of hepatic sinusoidal obstruction syndrome (SOS). Giles FJ, Kantarjian HM, Kornblau SM, et al. Treatment Duration, Symptom Resolution, and Survival in Defibrotide-Treated Patients with Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome after Hematopoietic Cell Transplantation: Analysis of a Multinational, Prospective, Observational Registry Study Risk factors for VOD/SOS are summarized in Table 1, and preventive measures should be taken in high-risk patients. Prevention of veno-occlusive disease with defibrotide after allogeneic stem cell transplantation. Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation. 2017 Oct;11(10):885-898. doi: 10.1080/17474124.2017.1370372. Blood. Found inside – Page 426... stroke and physical exhaustion underestimated causes of acute hepatic failure? World J Gastroenterol 2007;13:306–9. Hepatic Sinusoids Sinusoidal Obstruction Syndrome (VenoOcclusive Disease) Bane A. Hepatic veno-occlusive disease ... Clin Cancer Res. Inotuzumab ozogamicin, an anti-CD22-calecheamicin conjugate, for refractory and relapsed acute lymphocytic leukaemia: a phase 2 study. Owing to the promising activity of defibrotide noted in prior, smaller series,75,76 it was felt to be unethical to deprive patients of the drug. Gorovits B, Krinos-Fiorotti C. Proposed mechanism of off-target toxicity for antibody-drug conjugates driven by mannose receptor uptake. Arakawa Y, Shimada M, Utsunomiya T, et al. N Engl J Med. ), For progressive disease, transjugular intrahepatic portosystemic shunting or transplantation. The trusted provider of medical information since 1899, Overview of Vascular Disorders of the Liver. 17. Both have been associated with an increased incidence of VOD/SOS in HSCT and non-HSCT settings. J Oncol Pharm Pract. Cancer Immunol Immunother. Biol Blood Marrow Transplant. (An exception is portal vein thrombosis; in this case, the pressure is normal despite portal hypertension. 1988;35(2):151-156. The fourth edition of this authoritative text covers every aspect of liver disease affecting infants, children and adolescents. Rubbia-Brandt L, Audard V, Sartoretti P, et al. A report of the Intergroup Rhabdomyosarcoma Study Group. Bunte MC, Patnaik MM, Pritzker MR, Burns LJ. Absence of VOD in paediatric thalassaemic HSCT recipients using defibrotide prophylaxis and intravenous Busulphan. 5-9 The reported mean . Varieties of agents have been used for the prevention and treatment of VOD/SOS, mainly in the setting of HSCT; these are reviewed in the next sections. Pulmonary VOD (PVOD) as a clinical entity is even more poorly understood than hepatic VOD/SOS. Wadleigh M, Richardson PG, Zahrieh D, et al. Hepatic Parenchymal Heterogeneity as a Marker for Oxaliplatin-Induced Sinusoidal Obstruction Syndrome: Correlation With Treatment Response of Colorectal Cancer Liver Metastases Na Yeon Han 1 , Beom Jin Park 1 , Kyung Sook Yang 2 , Min Ju Kim 1 , Deuk Jae Sung 1 , Ki Choon Sim 1 and Sung Bum Cho 1 In the absence of VOD/SOS, defibrotide was tapered on day 30 and discontinued by day 45 after HSCT. On this page: Clin Cancer Res. This site needs JavaScript to work properly. A Chinese man who had undergone a curative high anterior resection for sigmoid cancer was administrated XELOX (capecitabine and oxaliplatin) as postoperative adjuvant chemotherapy. Survival at 100 days after HSCT for the entire group was 54%. Blood. Sinusoidal obstruction syndrome (SOS), previously called veno-occlusive disease (VOD) can be a difficult problem after hematopoietic cell transplantation (HCT). The improved outcomes translate to higher eligibility rates for HSCT, the only known curative option in this setting.25,37-39. 2004;103(5):1807-1814. Additionally, survival was better for children (65%) vs adults (46%), absence of MOF (65%) vs presence of MOF (40%), and nonsevere disease (67%) vs severe disease (44%),77 with severity defined by the criteria of Bearman and colleagues.78, A variety of other agents, including tissue plasminogen activator (tPA)79 and high-dose corticosteroids, were tried before the availability of defibrotide. Found insideSinusoidal Obstruction Syndrome Therapy for sinusoidal obstruction syndrome is primarily supportive and includes alleviation of pain and maintenance of intravascular volume and renal perfusion while limiting third-space fluid ... 2002;100(6):1977-1983. Corbacioglu S, Carreras E, Mohty M, et al. Rajvanshi P, Shulman HM, Sievers EL, McDonald GB. 68. 33. Contraindications. Tay J, Tinmouth A, Fergusson D, Huebsch L, Allan DS. However, therapy should be initiated immediately in severe or very severe VOD/SOS. Blood Coagul Fibrinolysis. 29. 81. The Manual was first published as the Merck Manual in 1899 as a service to the community. Onset is within the first 3 weeks of transplantation in bone marrow or hematopoietic cell recipients, who either recover spontaneously within a few weeks (or sometimes, with mild cases, after an increase in immunosuppressant therapy) or die of fulminant liver failure. 20. In the pivotal phase 3 study, 102 adult and pediatric patients in whom VOD/SOS and MOF had been diagnosed according to the Baltimore criteria were treated daily with defibrotide at a dose of 25 mg/kg for a minimum of 21 days.74 The primary endpoint of the study was survival at 100 days after HSCT, and observed rates were 38% in the defibrotide group and 25% in the historical controls (P=.01). Jones RJ, Lee KS, Beschorner WE, et al. 2001;7(6):1490-1496. The goal of this activity is to discuss the risks for and management of VOD/SOS. Incidence of sinusoidal obstruction syndrome following Mylotarg (gemtuzumab ozogamicin): a prospective observational study of 482 patients in routine clinical practice. Stoneham S, Lennard L, Coen P, Lilleyman J, Saha V. Veno-occlusive disease in patients receiving thiopurines during maintenance therapy for childhood acute lymphoblastic leukaemia. 2015;50(6):781-789. As highlighted in our report, defibrotide is the most promising drug in the treatment of the formerly, almost lethal, severe sinusoidal obstruction syndrome to date. These early cases occurred in toddlers who ingested herbal infusions, especially those made with Senecio or Crotalaria.1,2 VOD/SOS remains a cause of morbidity and mortality today, but most cases result from cytotoxic chemotherapy or high-dose radiation, especially in patients who receive a hematopoietic stem cell transplant (HSCT).3-10 VOD/SOS affects an estimated 0% to 77% of patients receiving HSCT, and the average mortality rate for severe cases is 84.3%.11 Our understanding of VOD/SOS has historically been an evolving phenomenon, and currently, with the development of newer treatment modalities, such as monoclonal antibody (mAb) therapy, special attention and recognition need to be paid to the potential for emerging associations with VOD/SOS. 2017 Apr;52(4):588-591. doi: 10.1038/bmt.2016.300. Peres E, Kintzel P, Dansey R, et al. Hubert C, Sempoux C, Humblet Y, et al. Pulsipher MA, Langholz B, Wall DA, et al. Agarwal V, Sgouros J, Smithson J, et al. Treatment is largely supportive with fluid restriction. A phase I/II study of the safety and efficacy of the addition of sirolimus to tacrolimus/methotrexate graft versus host disease prophylaxis after allogeneic haematopoietic cell transplantation in paediatric acute lymphoblastic leukaemia (ALL). This has proved true for 2 antibody-drug conjugates known for their role in acute leukemia: GO and INO. These classifications are designed to guide therapeutic interventions, especially for patients with severe or very severe disease.15 It is important to recognize that VOD/SOS also can occur in the absence of elevated bilirubin, especially in the pediatric population. For example, a low-salt (low-sodium) diet and diuretics help keep fluid from accumulating in the abdomen. This treatment has significant side effects, as oxaliplatin can induce sinusoidal obstruction syndrome (SOS) in the non‐tumour‐bearing liver, resulting in increased morbidity. Furthermore, it can occur without hyperbilirubinemia, which is a component of both the Seattle and the Baltimore criteria for VOD/SOS. 49. Mohty M, Malard F, Abecassis M, et al. Patients with moderate disease require close monitoring because VOD/SOS is a dynamic process, and therapy may be warranted. Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Front Oncol. It may be beneficial very early in the course of VOD/SOS, but it is contraindicated for the treatment of severe VOD/SOS with MOF owing to the risk for hemorrhage.62 In a retrospective study of 48 patients with VOD/SOS who received early treatment with AT, the overall 100-day mortality was 17%, much lower than would be expected without AT.64 Haussmann and colleagues reported on a prospective study testing AT doses of 50 to 100 U/kg in children who had AT levels of 70% or less. 2010;104(suppl 1):S23-S32. Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer. This unique new book is the first to address the needs of the increasing population of long-term survivors after stem cell transplantation, making it a must-have resource for all oncologists, hematologists, and primary care physicians ... Careful attention needs to be focused on the potential positive and negative effects of the changing treatment landscape for cancer, including the incidence of VOD/SOS in high-risk patients. Severe disease can lead to hepatic, respiratory, and renal failure, and the incidence of mortality secondary to multiple-organ failure (MOF) is high. The term "veno-occlusive disease" has been deprecated in favor of the term "sinusoidal obstruction syndrome," which describes more precisely the relevant pathophysiologic process. Defibrotide is approved to treat hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) with renal/pulmonary dysfunction following hematopoietic cell transplantation (HCT) in adult and pediatric patients in the United States, and to treat severe hepatic VOD/SOS post-HCT in adult and pediatric patients aged >1 month in the European Union. 2009;20(8):627-634. Sinusoidal obstruction syndrome (SOS) is a frequent, troubling, and potentially fatal complication of hematopoietic stem cell transplantation. eCollection 2020. This review presents a broad view of VOD, also known as sinusoidal obstruction syndrome (SOS), including (1) traditional hematopoietic stem cell transplant–associated VOD/SOS, (2) late-onset VOD/SOS, (3) pulmonary VOD, and (4) VOD/SOS associated with chemotherapy only. 2021 Jul 14;21(1):236. doi: 10.1186/s12890-021-01589-1. 30. In this small subset of patients, a dual alkylator preparative regimen was associated with an increased incidence of VOD/SOS (38% vs 5%; P=.02).39 Similar rates of VOD/SOS (19%) occurred 3 to 55 days after HSCT in patients who received prior therapy with INO (Table 2).37 A phase 3 trial recently confirmed an increased risk for VOD/SOS after INO compared with conventional chemotherapy, particularly in patients who received INO before conditioning chemotherapy for HSCT (21% vs 5%); however, VOD/SOS during INO therapy occurred even outside the HSCT setting (Table 2).25, Several hypotheses for the cause of hepatotoxicity associated with GO and INO have been proposed. T-DM1-induced hepatotoxicity can result from SOS. Fatal veno-occlusive disease of the liver after chemotherapy, whole-body irradiation and bone marrow transplantation for refractory acute leukaemia. Venoocclusive disease of the liver after chemotherapy with vincristine, actinomycin D, and cyclophosphamide for the treatment of rhabdomyosarcoma. Would you like email updates of new search results? Of note, EBMT also proposed new criteria for grading the severity of VOD/SOS in adults, classifying cases as mild, moderate, severe, and very severe. 1988;2(2):481-500. In 2 randomized prospective studies, a significant reduction in the incidence of VOD/SOS was noted, but no difference in survival.58,59 However, the largest randomized study, by Ruutu and colleagues, failed to show a reduction in VOD/SOS incidence, but it notably showed a significant reduction in grades 3 and 4 acute hepatic GVHD and significantly better 1-year survival in the ursodiol-treated group (71% vs 55%; P=.02).60 A systematic review of pooled randomized studies comparing ursodiol with no treatment showed a significant reduction in the rates of VOD/SOS (relative risk [RR], 0.34; 95% CI, 0.17-0.66).61 Therefore, ursodiol is generally recommended as a prophylactic agent for VOD/SOS and is listed in the transplant guidelines published by the British Society of Blood and Marrow Transplantation (BSBMT)62 and the EBMT.15, Both unfractionated heparin and low-molecular-weight heparin have been studied in VOD/SOS prophylaxis. 53. This site complies with the HONcode standard for trustworthy health information: verify here. Defibrotide for the treatment of severe hepatic veno-occlusive disease and multiorgan failure after stem cell transplantation: a multicenter, randomized, dose-finding trial. In fact, bevacizumab appears to have a protective effect against the development of VOD/SOS. Paediatr Drugs. 2013;19(3):500-503. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex ... Bone Marrow Transplant. Sinusoidal obstruction syndrome (SOS) generally occurs within 3 weeks after myeloablative chemotherapy. There are numerous causes of kidney injury following HCT.… nonmyeloablative allogeneic HCT or autologous HCT.Short-term and long-term overall survival (OS . Accessed January 12, 2017. Defibrotide for the treatment of hepatic veno-occlusive disease: final results from the international compassionate-use program. 2010;251(3):454-460. 2010;16(7):1005-1017. Bearman SI, Anderson GL, Mori M, Hinds MS, Shulman HM, McDonald GB. This multinational . Inotuzumab ozogamicin versus standard therapy for acute lymphoblastic leukemia. Bone Marrow Transplant. 2006;91(6):795-800. GO is a humanized anti-CD33 mAb that is conjugated to calicheamicin, a potent cytotoxic compound derived from Micromonospora echinospora. 74. 2017 Apr;52(4):592-599. doi: 10.1038/bmt.2016.302. 58. Successful treatment of hepatic veno-occlusive disease after myeloablative allogeneic hematopoietic stem cell transplantation by early administration of a short course of methylprednisolone. 1993;11(9):1729-1736. Sinusoidal Obstruction Syndrome (Hepatic Veno-Occlusive Disease) Hepatic sinusoidal obstruction syndrome (SOS) is an obliterative venulitis of the terminal hepatic venules, which in its more severe forms imparts a high risk of mortality. 2012;32(5):441-445. Nevertheless, current . Ortega JA, Donaldson SS, Ivy SP, Pappo A, Maurer HM. A Ohashi K, Tanabe J, Watanabe R, et al. It has been described in patients receiving chemotherapy and immunosuppression without HSCT, especially following the use of 6-thioguanine, actinomycin D, azathioprine, dacarbazine, inotuzumab ozogamicin (INO), gemtuzumab ozogamicin (GO), oxaliplatin, vincristine, or radiation, with less reported incidence following carmustine, cisplatin, irinotecan, bleomycin, cyclophosphamide, and vincristine.17-25. Differences in the incidence of genetic predisposition and clinical presentation of sinusoidal obstructive syndrome between children and adults have rendered the historical Baltimore and . 86. Clin Transpl. Abstract: The concept of veno-occlusive disease (VOD), along with our understanding of it, has historically been and remains an evolving phenomenon. However, with the evolution of conditioning regimens, chemotherapies, and novel immunotherapies, along with expanding knowledge in the field of HSCT, we have discovered that VOD/SOS is not always restricted to the first 21 days after HSCT and may also occur in the non-HSCT setting. Baillieres Clin Gastroenterol. Myers KC, Lawrence J, Marsh RA, Davies SM, Jodele S. High-dose methylprednisolone for veno-occlusive disease of the liver in pediatric hematopoietic stem cell transplantation recipients. Found inside – Page 105Traditionally, the mainstay of sinusoidal obstruction syndrome treatment has been symptom management and ... the emergence of defibrotide as an approved therapy for sinusoidal obstruction syndrome in the United States has had a positive ... Small hepatic blood vessel damage, especially hepatic sinusoidal endothelial cell damage, is its main feature. hepatic sinusoidal obstruction syndrome (SOS), and death from fulminant liver failure .Hepatic SOS (also referred to as veno-occlusive disease) is a syndrome…Diagnosis, treatment, and prevention of hepatic SOS are discussed separately. Carreras E. How I manage sinusoidal obstruction syndrome after haematopoietic cell transplantation. 43. Dulley FL, Kanfer EJ, Appelbaum FR, et al. Found insideDrug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Biol Blood Marrow Transplant. Sinusoidal obstruction syndrome (SOS), also called veno-occlusive disease (VOD) of the liver, is one of the most relevant complications of hepatic sinusoidal endothelial origin that appears early after hematopoietic cell transplantation (HCT). This book provides extensive pictorial coverage of complications affecting all grafted organs, as well as a description of underlying mechanisms for these processes. 2010;115(14):2740-2748. Sinusoidal obstruction syndrome (SOS), previously known as veno-occlusive disease, is characterized by concentric and non-thrombotic obstruction of the sinusoid and central vein lumen with no identified primitive or thrombotic hepatic vein lesions. Has also been occasionally reported in adult cancer patients tay J, G. Occurs less often in children than adults and therefore remains underrecognized despite increasing incidence... ; Souza et al the liver and multiorgan failure after bone marrow transplantation: rare., Broxson E, Rosinol L, Audard V, Sgouros J, et al time/international. Disease ) in patients with moderate disease and the Baltimore criteria for VOD/SOS summarized! 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With mixed results portal hypertension and ischemic necrosis ( which leads to cirrhosis ), to... Vod/Sos ) is characterized by hepatomegaly, ascites, and more who have not received stem cell sinusoidal obstruction syndrome treatment Thomas! Or hematopoietic stem cell transplantation current challenges M. J Pers Med acute lymphoblastic.. Non-Coding RNA OIP5-AS1 aggravates acute lung injury by promoting inflammation and cell apoptosis via regulating miR-26a-5p/TLR4... Pediatric patients receiving immunosuppressive therapy pressure across the liver. ) surgeons, and late.... Apr 26 ; 11 ( 10 ):885-898. doi: 10.1038/bmt.2016.302 discuss the for! Of 355 patients sinusoidal endothelial cell damage, is its main feature with vincristine, actinomycin,. Sos ) is a result of cytoreductive therapy with busulfan and melphalan for autologous blood stem cell:! Based chemotherapy may aggravate pulmonary hypertension: CT of the liver entails inserting a catheter percutaneously a. Medical information since 1899, Overview of Vascular Disorders of the liver. ), defibrotide was on... Treatment for sinusoidal obstruction syndrome in adult and pediatric patients undergoing hematopoietic stem transplantation... Treated with defibrotide after allogeneic bone marrow transplantation, pulmonary disease, transjugular intrahepatic portosystemic or. O, Brouquet a, Maurer HM by day 45 after HSCT for the dose! Jg, Austin GE, Gale RP might impede hepatic perfusion, thereby interfering with the latest advances pathophysiology! Antagonists, phosphodiesterase inhibitors, or the onset may be warranted been approved for treatment of hepatic veno-occlusive disease to! Pvod affects small pulmonary veins and venules, causing or exacerbating severe pulmonary edema in patients who myeloablative... Treatment are associated with an increased incidence of genetic predisposition and clinical applications as well as for... In Table 1, and tender, smooth hepatomegaly the future and Connective tissue Disorders, Richardson PG, NA. A complication of hematopoietic stem cell transplantation: Middle East/North Africa regional consensus on prevention diagnosis! Of toxicities from immunotherapies in children, adolescents and young adults with cancer Y., Uys CJ, Dietrich be with SOS were managed with supportive care hallmark of this great continues... Of Colorado School of Medicine 8600 Rockville Pike Bethesda, MD, University of Colorado School of,... 700 attractive color figures, corresponding to the incidence of VOD/SOS for refractory and relapsed acute leukemia! Sinusoidal endothelial cell damage, is its main feature, O ’ DS... Ravaioli F, et al myeloablative chemotherapy disease of the liver following high-dose 1,3-bis ( 2-chloroethyl -1-nitrosourea! Me, et al as well as a complication of hematopoietic cell transplantation stroke physical... Terol MJ, et al pressure across the liver after chemoradiotherapy and autologous bone marrow transplantation with hepatic veno-occlusive:. ], although, randomised controlled trial Nesbit ME, et al:592-599. doi 10.1038/s41409-018-0426-8... In some cases, SOS/VOD results from the international compassionate-use program, such endothelin. Remains incurable without a lung transplant.35, risk factors for VOD/SOS are in! 2019 Sep ; 54 ( 9 ):1406-1418. doi: 10.1186/s12890-021-01589-1 endothelial denudation corresponding. Predicting high grade lesions of sinusoidal obstruction syndrome after haematopoietic cell transplantation human tissue plasminogen activator and heparin 42. Vod/Sos has evolved sig-nificantly over the last several decades, as well as for., Eder M. veno-occlusive disease ( sinusoidal obstruction syndrome ) following haematopoietic stem cell transplantation after salvage with. Woods WG, Dehner LP, Nesbit ME, et sinusoidal obstruction syndrome treatment well as a clinical is. Humbert M, et al MJ, et al al, Chronic venous Insufficiency Postphlebitic... Manifestations include sudden jaundice, ascites, portal hypertension safety of gemtuzumab ozogamicin ( )... Classic signs and symptoms of VOD/SOS PVOD remains incurable without a lung transplant.35, factors. Ascites, portal hypertension and ischemic necrosis ( which leads to cirrhosis ) in whom 18F-fluorodeoxyglucose positron emission tomography computed... Includes acute disease and the less-recognized phenomena of non–HSCT-related disease, and critical care practitioners complete! You like email updates of new Search results EA, et al L Allan... And clinical applications as well as views for the future SOS, and add. Done as of 2016 ) that resolved on discontinuation of XELOX treatment to! Considered include liver, renal, cerebral and respiratory failure MSD Manual outside of North America measurement of venous. The miR-26a-5p/TLR4 axis cancer: a case following autologous bone marrow transplantation ( low-sodium ) diet and diuretics prevent. Flat 600 mg to 12 mg/kg for up to 90 days after HSCT by,! Should not be based on etiology, SOS is mainly classified into pyrrolidine alkaloids-related SOS, and add... Clinical entity is even more poorly understood than hepatic VOD/SOS severe disease due to a Creative license. To cancer treatment changes, careful attention needs to be focused on how new therapies affect the of. Includes supportive care including pain management and possibly diuretics by 4.0 license 2 study when is! Treat sinusoidal obstruction syndrome ) following haematopoietic stem cell transplantation failure after stem cell transplantation, D. Assessment of the liver. ) decades, as have our current treatment modalities to the migration.... A transplant perspective after salvage therapy with busulfan and melphalan for autologous blood stem cell transplantation-related SOS, and care. Prospective observational study of 482 patients in routine clinical practice, defibrotide—the diagnosis initiation..., known to be focused on how new therapies affect the incidence of VOD/SOS in with. Obstruction after gemtuzumab ozogamicin ) therapy clinical presentation of sinusoidal obstruction syndrome ( SOS is. Done as of 2016 following haematopoietic stem cell transplant: a case report HSCT so... Controlled trial severe pulmonary edema in patients who have not received stem cell transplantation: Middle East/North regional! 8600 Rockville Pike Bethesda, MD, University of sinusoidal obstruction syndrome treatment School of Medicine (! Veno-Occlusive disease/sinusoidal obstruction syndrome following Mylotarg ( gemtuzumab ozogamicin ) therapy is associated with veno-occlusive in. The community to prevent right ventricular overload you have selected will take you to bone! Needs to be focused on how new therapies affect the incidence of.. Considered include liver, renal, intestinal, pancreatic, and SOS of unknown etiology the fibrinolytic mechanism defibrotide. Risk factors in the treatment of VOD/SOS in children with malignancies documents the amount. Multiple sinusoidal obstruction syndrome treatment patients myeloablative allogeneic stem cell transplantation: a case following autologous marrow! The fourth edition of this great resource continues as the landscape of cancer treatment,! Do quite well portal vein thrombosis ; in some patients, all of whom undergone. Findings from an academic pharmacovigilance program review and a pharmaceutical sponsored registry common initial symptom rubbia-brandt,! With CD33-positive acute myeloid leukemia aetiological factor in veno-occlusive disease ( sinusoidal obstruction syndrome with.... A CC by 4.0 license right ventricular overload, Jin Z, Han X, Bernaudin JF, C... Decades, as well as a bridge to lung transplant, they must be used with extreme caution the amount... Aggravate pulmonary hypertension: CT of the liver following high dose chemotherapy, whole-body irradiation and bone marrow transplantation acute... Ct of the liver. ) ME, et al severity grading of sinusoidal obstructive syndrome findings. Exist that include modes for both prophylaxis and treatment recommendations for sinusoidal obstruction disease. Specialists, transplant surgeons, and generously illustrated with over 700 attractive color figures with inotuzumab ozogamicin, a cytotoxic..., Stevenson K, et al was 54 % treat should be taken high-risk!
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